Mequinol CAS NO.150-76-5

4-Methoxyphenol is produced from p-benzoquinone and methanol via a free radical reaction.[  Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass.Dermatologists commonly prescribe the drug to treat solar lentigines, liver spots, or age spots.   

Mequinol

• Molecular Formula :C₇H₈O₂
• Other name :4-Methoxyphenol
  
• CAS NO. : 150-76-5
• Molecular weight : 124.14
• EINECS NO. ：205-769-8
  
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Pharmacodynamics of  Mequinol

Mequinol is in fact considered a melanocytotoxic chemical which when oxidized in melanocytes results in the formation of toxic entities like quinonesSuch cytotoxic compounds subsequently have the potential to damage and destroy pigment cells, therefore causing skin depigmentation [3]. In response, skin cells are naturally capable of protecting themselves against such cytotoxic agents with the help of endogenous intracellular glutathione and the detoxification action of glutathione S-transferase on the cytotoxic compounds . Regardless, it is consequently by way of this seemingly negative and damaging pharmacodynamic profile by which the mechanism of action of mequinol is sometimes described

Safety

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Mequinol and tretinoin can cause some stinging, burning, warmth, tingling, itching, redness, swelling, dryness, peeling, or other skin irritation. Stop using the medication and call your doctor if any of these side effects become severe. You may need to use less of the medication or apply it less often.