TOP Quality Best Price Ceramide 2.5% Powder

Product Name:2.5% ceramide

Active ingredients: Ceramide

Molecular formula: C34H66NO3R

Molecular weight: 536.89

CAS Number:  104404-17-3
Test Method: HPLC 

Min Order: 1kg

Valid: 60 days

Shelf life: 2 years

Standard Packing: 25kg/dram

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Ceramides powder are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of cells, since they are component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer.
As a bioactive lipid, ceramide has been implicated in a variety of physiological functions including apoptosis, cell growth arrest, differentiation, cell senescence, cell migration and adhesion. Roles for ceramide and its downstream metabolites have also been suggested in a number of pathological states including cancer, neurodegeneration, diabetes, microbial pathogenesis, obesity, and inflammation.

There are three major pathways of ceramide generation. 1. The sphingomyelinase pathway uses an enzyme to break down sphingomyelin in the cell membrane and release ceramide. 2. The de novo pathway creates ceramide from less complex molecules. 3. Ceramide generation can also occur through breakdown of complex sphingolipids that are ultimately broken down into sphingosine, which is then reused by reacylation to form ceramide.

1.Apoptosis

One of the most studied roles of ceramide powder pertains to its function as a proapoptotic molecule. Apoptosis, or Type I programmed cell death, is essential for the maintenance of normal cellular homeostasis and is an important physiological response to many forms of cellular stress. Ceramide powder accumulation has been found following treatment of cells with a number of apoptotic agents including ionizing radiation, UV light, TNF-alpha, and chemotherapeutic agents. This suggests a role for ceramide in the biological responses of all these agents.

2.Skin
Ceramide powder is the main component of the stratum corneum of the epidermis layer of human skin. Together with cholesterol and saturated fatty acids, ceramide creates a water-impermeable, protective organ to prevent excessive water loss due to evaporation as well as a barrier against the entry of microorganisms.

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