Reserpine is extracted from the root of Rauwolfia serpentina or Rauwolfia vomitoria, plants found in India and Africa. Reserpine was the first drug found to interfere with the human sympathetic nervous system, and it initiated the effective pharmacotherapeutic control of hypertension. Reserpine is a naturally occurring drug that has been used for centuries in ancient India.
Reserpine is an anti-adrenergic drug. Reserpine is a Postganglionic sympathetic nerve terminal blocker. Reserpine reduces the cardiac output by negative isotropic effect and negative chronotropic effect. Similarly by reducing sympathetic activity to blood vessels, Reserpine relaxes capacitance vessels and reduces total peripheral resistance.
Application&Function
1. Reserpine was blocked by adrenergic neurons of antihypertensive drugs. 2. This product is the depletion of peripheral sympathetic nerve endings of adrenaline, heart, brain and other tissues of catecholamines and 5 – HT to anti-high blood pressure, slow heart rate and inhibition of the central nervous system. Antihypertensive effect primarily by reducing cardiac output and reduced peripheral resistance, part of the cardiovascular reflex inhibition to achieve. 3. Reserpine acts on hypothalamic area produce sedation, but no cause drowsiness and anesthetic effects, does not change the sleep EEG, can ease the anxiety of patients with hypertension, tension and headaches. 4. Experimental animal for less than the clinical dose of reserpine, which appears miosis, eyelid wrinkles and sagging, hypothermia, gastrointestinal symptoms such as the acceleration of activity.
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