Arthritis Supplements- Glucosamine, Chondroitin, and MSM Many people with arthritis — especially osteoarthritis — use supplements in their diet to ease the pain of arthritis. Glucosamine and chondroitin are the most well-known. Methyl sulfonylmethane (MSM) is another supplement used to ease the pain of arthritis, but it has not been through as much scientific testing. It is important …