Nisin (CAS 1414-45-5, E234) is a natural lantibiotic peptide produced by Lactococcus lactis fermentation. It inhibits Gram-positive bacteria including Listeria, Staphylococcus and Clostridium — the most widely used natural antibacterial preservative in dairy, meat and canned foods.
Physical & Chemical Properties
- CAS number: 1414-45-5
- Appearance: white to off-white powder
- Solubility: soluble in dilute acids; sparingly soluble in water
- Molecular formula: C143H230N42O37S7
- Molecular weight: 3354.07
- Activity: 1 million IU/g (standard)
- Regulatory: food preservative E234 (EU/China), GRAS (US)
Key Benefits for Formulation
- Broad anti-Gram-positive: Listeria, Staph, Clostridium, Bacillus
- Heat stable: survives thermal processing
- Clean label: natural fermentation, E234 approved
- Synergistic: works with heat, low pH & EDTA systems
- Low use level: ppm-level efficacy
Main Applications
- Dairy: cheese, processed cheese & milk products
- Meat & poultry: Listeria control in RTE products
- Canned foods: thermophilic spoilage prevention
- Beverages: low-pH juice & beer stabilization
- Fermented foods: spoilage organism control
Why Choose Our Bulk Nisin?
- GMP manufacturing: full quality control from raw material to finished product
- Complete documentation: COA, SDS and heavy metal test reports available on request
- Flexible supply: multiple purity grades in stock, from R&D samples to mass production
- Export experience: reliable shipping to EU, North America, Australia and Middle East
Recommended Usage
Typical use 5–25 ppm active nisin depending on product matrix and target organisms. Verify permitted levels for your market and category.
FAQ About Wholesale Nisin
What is the CAS number of Nisin?
CAS 1414-45-5.
What is nisin?
A natural lantibiotic peptide produced by Lactococcus lactis fermentation (E234).
What activity is available?
Standard 1 million IU/g; other strengths available.
Which bacteria does it control?
Gram-positive bacteria — Listeria, Staphylococcus, Clostridium, Bacillus.
Is it heat stable?
Yes — survives typical thermal processing.
Is it suitable for cheese?
Yes — dairy is the most common application.
Do you provide COA and SDS?
Yes — full COA, SDS and heavy metal reports available on request.
What is the shelf life?
Typically 24 months stored sealed in a cool, dry place.
Can I get samples?
Yes — trial samples available; terms negotiable with bulk orders.
What are your MOQ terms?
Flexible MOQ, discussed on inquiry.
Start Your Nisin Bulk Order
Contact our sales team today for spec sheets, samples and bulk pricing — our technical team is ready to support your formulation development.
